Journal article
BCL-XL inhibition by BH3-mimetic drugs induces apoptosis in models of Epstein-Barr virus-associated T/NK-cell lymphoma
N Sejic, LC George, RJ Tierney, C Chang, O Kondrashova, RN MacKinnon, P Lan, AI Bell, G Lessene, HM Long, A Strasser, C Shannon-Lowe, GL Kelly
Blood Advances | ELSEVIER | Published : 2020
Abstract
Epstein-Barr virus (EBV)-associated T- and natural killer (NK)-cell malignancies, such as extranodal NK-/T-cell lymphoma (ENKTL), exhibit high chemoresistance and, accordingly, such patients have a poor prognosis. The rare nature of such cancers and nonmalignant T/NK lymphoproliferative disorders, such as chronic active EBV (CAEBV), has limited our understanding of the pathogenesis of these diseases. Here, we characterize a panel of ENKTL- and CAEBV-derived cell lines that had been established from human tumors to be used as preclinical models of these diseases. These cell lines were interleukin-2 dependent and found to carry EBV in a latency II gene-expression pattern. All cell lines demons..
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Grants
Awarded by State Government of Victoria
Funding Acknowledgements
This work was supported by funding from the Victorian Cancer Agency Fellowship (MCRF 17028) (G.L.K.), Cancer Council Victoria, grants-in-aid #1086157 and #1147328 (G.L.K.); the National Health and Medical Research Council (NHMRC), project grant #1086291 (G.L.K.), program grant #1113133 (A.S.), fellowship #1020363 (A.S.); the Leukaemia FoundationAustralia grant (G.L.K. andA.S.); the Leukemia & Lymphoma Society grant #7015-18 (A.S.); the estate of Anthony (Toni) Redstone OAM, The Craig Perkins Cancer Research Foundation, and The Dyson Bequest; operational infrastructure grants through the Australian Government NHMRC Independent Research Institutes Infrastructure Support Scheme (IRIISS) and the Victorian State Government Operational Infrastructure Support; a Universitas 21 project grant (C.S.-L., H.M.L., and G.L.K.); and the Medical Research Council, Research Grant #MR/N023781/1 (C.S.-L.)